The train station in Winona, Mississippi, has a storied past tied closely to the town’s development. Established due to the construction of the railroad, the station played a crucial role in Winona’s growth and was integral to its business and trade activities. The Illinois Central Railroad depot, located at 100 North Front Street, served as a key stop for passengers traveling through Mississippi, including the renowned Amtrak’s “City of New Orleans” route until service ended in 1995. This cessation marked the end of 135 years of rail service in the area.

The depot, designed in the early 20th century, is noted for its historical and architectural significance. The station contributed significantly to Winona’s economic and social life, attracting settlers and businesses around the area. Despite its unstaffed status today, the depot remains a notable landmark, reflecting the rich railroad heritage of Winona.